Journal article
Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand
ZSJ Liu, J Sattabongkot, M White, S Chotirat, C Kumpitak, E Takashima, M Harbers, WH Tham, J Healer, CE Chitnis, T Tsuboi, I Mueller, RJ Longley
BMC Medicine | Published : 2022
Abstract
Background: Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the disease malaria in low-transmission regions outside of Africa. These regions often feature high proportions of asymptomatic patients with sub-microscopic parasitaemia and relapses. Naturally acquired antibody responses are induced after Plasmodium infection, providing partial protection against high parasitaemia and clinical episodes. However, previous work has failed to address the presence and maintenance of such antibody responses to P. vivax particularly in low-transmission regions. Methods: We followed 34 patients in western Thailand after symptomatic P. vivax infections to monitor antibody kinetics over..
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Grants
Awarded by Case Western Reserve University
Funding Acknowledgements
Funding was provided by the National Health and Medical Research Council (#1092789, #1134989, and #1043345 to IM, #1143187 to W-HT, and #1173210 to RL), the Global Health Innovative Technology Fund (https://www.ghitfund.org/) (T2015-142 to IM) and the National Institute of Allergy and Infectious Diseases (NIH grant 5R01 AI 104822 to JS). We acknowledge support from the National Research Council of Thailand and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. W-HT was a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (https://www.hhmi.org/programs/biomedical-.research/inter national-.programs,~208693/Z/17/Z). ZS-JL was supported by the Melbourne Research Scholarship, University of Melbourne.